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Nervous tissue develops from the embryonic ectoderm. It is composed of two cell types: neurons and glia. The main function of nervous tissue is the processing of information coming from the external and internal environments, and then triggering a response. It is also responsible for controlling many vital functions such as breathing, digestion, heart blood pumping, regulation of blood flow, control of endocrine system, and many others.

Image of a section of the rat cerebral cortex stained with cresyl violet, where many neuronal cell bodies are observed.
A mouse brain cortical neuron after Golgi technique.

Nervous tissue constitutes the central nervous system, including the brain and spinal cord, as well as the peripheral nervous system, including nerve ganglia, nerves and neurons scattered throughout the body.

Neuronal bodies and processes (dendrites and axons) make up most of the nervous tissue. However, scarce extracellular matrix is also present, which is enriched in glycoproteins. Extracellular matrix is involved in many functions such as cell movement, axonal growth, path finding, and formation and function of synapses.

Nervous tissue is made up of cell bodies of neurons and glia. Cell body is the part of the cell containing the nucleus and most of the cytoplasm. However, much of the tissue is made of cytoplasmic processes or neurites: dendrites and axons, ang glial cytoplasm extensions. Areas containing mainly dendrites and axons are known as neuropil. The nervous system also contains a small amount of extracellular matrix with high proportion of glycoproteins.

There are parts of the central nervous system with many and tightly packed cell bodies of both neurons and glia. In fresh tissue, these areas show a grayish color so that they are known as gray matter. Other parts of the central nervous system are poor in cell bodies and are mostly made up cellular processes (mainly myelinic axons). In fresh nervous tissue, these areas are whitish, so that they are known as white matter. White matter is where the larger axonal tracts are located. In the encephalon (brain), the gray matter is usually located superficially whereas in the spinal cord is found in a deep location.

Both the encephalon and the spinal cord are irrigated by blood vessels. The blood supply to different nervous areas can be modulated by changing the diameter of the arteries and capillaries to allow changes in the neuronal activities. More neuronal activity needs more blood. Capillary diameter are regulated by pericytes. The blood flux has to be adjusted because nervous tissue is quickly damaged under low oxygen levels. Neurons die after a few minutes without oxygen, and damages caused are known as ischemia.

The nervous tissue is aisolated from the surrounding tissues. Capilllaries are composed endothelial cells form a sealed barrier by means of tight junctions. Furthermore, the endocytosis rate of the endothelial cells of the nervous system is lower than in other tissues. There is a layer of connective tissue, known as basal lamina, covering the endothelial cells, and wrapping the basal lamina there is a sheet of astrocytes processes, referred as glia limintans, covering the basal lamina. All together, endothelium, basal lamina, and glia limintans, make the hematoencephalic barrier. This barrier controls the interchange of substances between the nervous tissue and the blood. The encephalon and the spinal cord are also separated from the bone, skull and vertebrae respectively, by a membranes of tissue known as meninges.

Spinal cord
Spinal cord.

Neurons are specialized in transmitting information by means of changes in the electrical potential of the cell membrane. Morphologically, these cells can be divided in three compartments: cell body or soma (where the nucleus of the cell is located), axon and dendrites. The dendritic tree is the main recipient of the information coming from many other neurons and sensory receptors. It integrates all the incoming information and directs the outcome to the cell body, where more integration is produced. The axon, which arises from the cell body, carries the result of the processed information to other neurons or to muscle fibers.

Spinal  ganglia
Spinal ganglia.

The number, size and arrangement of dendrites is variable in different types of neurons, but there is only one axon per neuron (with some exceptions). Neurons communicate with each other, or with muscle cells, by using chemical mediators known as neurotransmitters. This occurs in particular parts of the neurons known as synapses, which consist of a neural presynaptic part, a synaptic cleft, and a postsynaptic part. Neurotransmitters are released by the presynaptic neuron into the synaptic cleft, they diffuse toward the surface of the postsynaptic neuron and bind to specific receptors. The binding of the neurotransmitters to receptors triggers a change in the membrane potential of the postsynaptic neuron. Sometimes, interneuronal communication is by gap junctions, known as electrical synapses.

Astrocitos y neuronas
Neurons and glia in the encephalon
A) Dark blue labeled neurons in the striatum. The cell bodies, where the nucleus and much of the cytoplasm are located, bear thin processes that are the dendrites. In this figure, only a few neurons are stained, but there are huge amount of neurons in this area which are not labeled. The labeled neurons contain the nitric oxide synthetase enzyme, and the activity of this enzyme produces the bluish staining.
B) Astrocytes located in the septal area showing a brown color. This color is the result of immunodetection of the glial fibrilar acid protein, a cytoskeleton protein, which is present in astrocytes, but not in neurons. The astrocyte morphology is visible because this protein is found in the cytoplasm.
Cell lineajes
Lineages of cells in the nervous system. CNS: central nervous system, PNS: peripheral nervous system.
Spinal cord ependyma
Spinal cord ependyma.

Glial cells, unlike neurons, can divide by mitosis and are as numerous as neurons in the central nervous system. There are several types of glial cells: astrocytes, Schwann cells, oligodendrocytes and microglia. Glia shows a number of functions. Astrocytes wrap blood vessel of the central nervous system, cover the surface of the encephalon and spinal cord, and are present as a third element of synapses, the other two being the presynaptic and postsynaptic neurons. Although astrocytes have been considered only as mechanical and metabolic support of neurons, they are also involved in modulating the synaptic activity. In addition, they proliferate in brain wounds and strokes, occupying the place of dead neurons. Oligodendrocytes and Schwann cells form myelin sheaths around the axons in the central and in the peripheral nervous system, respectively. Microglia is involved in functions like defense against pathogens and in damages of the nervous tissue because they act as phagocytes. Microglia cells do not differentiate from the cell lineage that gives rise to neurons and other glial cells, instead they are generated in the bone marrow, and come out from blood vessels to populate the nervous tissue.

Glial cells. A, C y D: astrocytes in the encephalon. B: astrocytes are much smaller than neurons. E: Bergmann glia located in the cerebellar cortex.
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Updated: 2019-06-30. 21:42